Identification of interferon stimulated genes that limit HCV replication and predict therapeutic outcome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508088

Funding Status
Closed

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Funded Activity Summary

The only treatment for hepatitis C is Interferon-ribavirin combination therapy. Interferon works by stimulating the liver cells to produce antiviral proteins that can control hepatitis C virus replication, however we do not know which proteins are responsible. The aim of this proposal is to identify those proteins that can limit HCV replication using both a laboratory based and clinical approach and to identify markers that will predict treatment outcome.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $389,224.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antiviral | Gene Expression | Hepatitis C Virus | Host antiviral response | Interferon | interferon therapy HCV | liver disease | microarray

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