Physiological function of Nedd4-2 in regulating the epithelial sodium channel

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508086

Funding Status
Closed

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Funded Activity Summary

The epithelial sodium channel (ENaC) controls sodium balance, blood volume and blood pressure. Abnormal regulation of ENaC is associated with conditions such as hypertension and pulmonary oedema. Delineating the regulation of ENaC is vital in understanding disease mechanisms and in defining targets for novel therapeutics for the treatment of disorders that arise due to sodium imbalance. This grant will enable us to understand how ENaC is regulated by a novel protein known as Nedd4-2.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $805,797.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry and molecular biology | cardiovascular disease and hypertension | epithelial transport | ion channel dysfunction | knockout mice | lung function | renel diseases | sodium channel | ubiquitin | ubiquitin-mediated proteolysis

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