Roles of Ndfip1 and Ndfip2 as adaptors for the Nedd4 family of ubiquitin ligases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508085

Funding Status
Closed

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Funded Activity Summary

Part of this proposal is to understand how the body controls iron uptake through one of the iron transporters (DMT1). We will also study how proteins called Ndfip1 and Ndfip2 that regulate DMT1, also control other cellular processes, such as protection against brain damage following trauma. The results from this study should ultimately contribute to the development of therapies for certain human pathologies.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $656,395.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Nedd4 family of ubiquitin ligases | biochemistry and molecular biology | cell death- apoptosis | disease mechanisms | haemochromatosis | iron deficiency | iron transport | protein-protein interaction | traumatic brain injury | ubiquitin

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