Pathophysiology and prevention of methotrexate chemotherapy-induced bone growth defects

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508046

Funding Status
Closed

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Funded Activity Summary

Childhood chemotherapy often causes growth arrest, osteoporosis, and fractures in cancer patients and survivors. Using a rat model, this project will study how the most commonly used chemotherapy drug methotrexate causes bone growth defects and examine any protective effects of two natural-derived substances. This work will increase our knowledge on chemotherapy-induced bone growth defects, and will be useful for developing a preventative treatment.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $622,598.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bone growth arrest | Bone growth defects | Chemotherapy toxicity | Childhood cancer | Childhood cancer chemotherapy | Growth plate and bone defects | Osteoporosis | Pathophysiological mechanisms | Prevention treatment strategies | Treatment strategies

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