Molecular Genetics of Polycythemia Vera

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508023

Funding Status
Closed

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Funded Activity Summary

We propose to use a number of genetic approaches to identify key mutations involved in Polycythemia vera. We will analyse patient material, use cell lines and mouse models to investigate any new mutations. We also aim to dissect the role of an important blood cell surface receptor and its cooperation with the mutation in JAK2 recently shown to be important in this disease. These approaches will lead to better understanding of the disease and potential new diagnostic and drug strategies.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $638,279.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

JAK-STAT pathway | cytokine receptor | genetic predisposition to disease | haemopoiesis | mutation screening | mutations | myeloid leukaemia | myelopoiesis | myeloproliferative disorders of the haemopoietic system | signaling

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