Mechanisms of premature cranial fusion: role of retinol binding protein 4 in osteogenesis and suture fusion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/508000

Funding Status
Closed

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Funded Activity Summary

Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $555,855.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone | bone fusion | cell culture | cell differentiation | cell growth-differentiation | craniofacial malformations | craniosynostosis | gene expression | genetic disease of bone

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