The Role of Connexin40 in the Pathogenesis of Atrial Fibrillation Probed by Targeted In Vivo Gene Transfer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/503802

Funding Status
Closed

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Funded Activity Summary

Atrial fibrillation (AF) is a fast and irregular heart rhythm that can predispose sufferers to heart failure and stroke. AF occurs as the result of abnormal electrical conduction in the upper heart chambers. We have found that a protein called Cx40 causes abnormal conduction in heart cells when grown in culture. The aim of this research is to see if AF occurs when Cx40 is increased and prevented when Cx40 is decreased in an AF animal model, potentially defining Cx40 as new therapeutic target.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $529,015.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Arrhythmia | Atrial Fibrillation | Conduction | Connexin | Gap Junction | Gene Transfer | cardiovascular disease

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