Mechanisms underlying the effects of TNFalpha in bone and haemopoiesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/502612

Funding Status
Closed

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Funded Activity Summary

Recent studies have identified that bone plays an important role in blood cell production. We have discovered that elevated levels of TNF alpha (which increases with ageing and can negatively impact on health) contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells and bone in this mouse model. In these studies we will determine how TNFalpha contributes to blood and bone defects, which may lead to better treatment of such diseases.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $589,425.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Ageing | Bone | Bone marrow transplantation | Genetic diseases of the blood | Haemopoiesis | Haemopoietic Stem Cells | Leukaemia | Osteoporosis | Retinoic acid receptors | TNF alpha

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