The mechanism of action of new 5-nitroimidazole drugs which are effective against metronidazole-resistant Giardia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/496640

Funding Status
Closed

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Funded Activity Summary

We have discovered new 5-nitroimidazole drugs which can overcome giardial resistance to metronidazole, the most prescribed 5-nitroimidazole drug to treat giardiasis. We will focus on defining mechanisms of action of these new 5-nitroimidazole drugs in the anaerobic gut protozoan parasite Giardia. Using biochemical techniques, we will determine whether our potent new drugs are activated more efficiently by the same mechanisms as metronidazole or by novel enzyme pathways in the parasite.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $292,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Biochemistry | Drug discovery | Drug resistance | Infectious disease | Intestinal disease | Microbial protozoan parasites | Parasitology | drug development | drug resistance | gene expression

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