Role of Chemoattractants in Hepatic Stellate Cell Recruitment and Fibrogenesis in Paediatric Cholestatic Liver Disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/496602

Funding Status
Closed

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Funded Activity Summary

This project investigates how decreased bile flow in children's liver diseases such as cystic fibrosis and biliary atresia, leads to the release of molecules from the liver which cause recruitment of scar-forming cells. This results in cirrhosis (liver scar) and the necessity for liver transplantation. This project will investigate whether some children are more susceptible to liver scarring due to mutations in genes which cause increased release of these recruitment molecules from the liver.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $589,175.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Bile acids | Biliary Atresia | Cholangiopathy | Cholestatic Liver Disease | Cystic Fibrosis Liver Disease | Hepatic Fibrosis | Hepatic Stellate Cell | Idiopathic Neonatal Hepatitis | Liver Transplantation | Paediatrics

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