Mineralocorticoid receptor co-regulator recruitment determines ligand specific signalling.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/494811

Funding Status
Closed

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Funded Activity Summary

Heart disease is a major cause of death and economic burden in Australia and throughout the world. The steroid hormone aldosterone controls salt and water balance,blood pressure and hasa significant role in heart failure. Although drugs that block the aldosterone receptor significantly help patients with heart failure, their use is limited by side effects. This work will identify the profile of proteins that promote aldosterone effects and enable the development of heart-specific blockers.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $491,530.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

aldosterone | cardiac failure | cardiovascular disease | coactivators | cortisol | inflammation | mineralocorticoid receptor | novel treatments | oxidative stress | ration al drug design

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