Transgenic expression of the EWS-WT1 fusion protein,inducing the development of tumour that replicates the human disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491305

Funding Status
Closed

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Funded Activity Summary

A genetic translocation encoding the EWS-WT1 fusion protein is found desmoplastic small round cell tumours. Our aim is to examine the effect of this protein in inducing tumour growth in tissue cell lines. A virus will then be used to introduce the genetic translocation into mice to examine the effect of this protein on tumour growth in a mammal, thereby serving as a 'solid tumour model' to try and identify therapeutic targets.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $112,976.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

lentiviral vector | oncogenesis | transgenic animals

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