Liver cell transplantation for the treatment of liver based metabolic diseases.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491256

Funding Status
Closed

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Funded Activity Summary

We propose to investigate the role of liver cell transplantation (LCT) for the therapy of inherited liver-based metabolic diseases using a methylmalonic aciduria (MMA) mouse model. LCT provides an exciting alternative to whole organ transplantation. Initially it was considered liver cells would be immunopriviledged. This has not proven to be the case. Immune modulation will be important. We will also examine immune modulation using antibodies to optimise longterm survival of allogeneic cells.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $444,143.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Genetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cell Therapy | Cell biology | Cell therapy | Inherited Metabolic Disorders | Inherited metabolic disorders | Liver | Transplantation

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