Histone H3.3 dynamics at the telomere in pluripotent embryonic stem cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491242

Funding Status
Closed

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Funded Activity Summary

The telomere is required for the protection of the chromosome ends. Telomere loses its repeat during each cell division, so telomere shorthening is one of the mechanisms underlying organismal aging as critically short telomeres induce chromosome instability and cell death. Defective telomeres can also result in genetic diseases and development of cancers. Here, we propose to study the mechanism that operates to ensure continual telomere renewal without senescence in embryonic stem cells.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $571,977.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

abnormal development | cancer | cell differentiation | chromatin structure | chromosomal abnormality | chromosomal disorder | chromosomal mapping | embryonic stem cell | genetic diseases | telomeres

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