Novel actions of beta-adrenoceptor antagonists: implications for the treatment of cardiac failure

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491190

Funding Status
Closed

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Funded Activity Summary

Almost 2-3 of drugs on the market act on G protein-coupled receptors, and many are antagonists that block receptors. Antagonists were seen as inert compounds that prevent access of natural neurotransmitters or hormones, but recent studies indicate distinct actions. We believe that atypical effects of beta-adrenergic antagonists may explain their usefulness in treating cardiac failure. We seek to understand the process and develop assays to aid the development of new drugs for cardiac failure.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $142,630.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | GPCR signal transduction mechanisms | antagonist | beta-adrenoceptor | cardiac fibrosis | cardiomyopathy | hypertension

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