Regulation of leukocyte lifespan by granzyme B and PI-9

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491176

Funding Status
Closed

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Funded Activity Summary

To fight infection or cancer the body produces specialized cells called cytotoxic lymphocytes (CLs) which target and eradicate abnormal cells. The number of CLs increases dramatically during infection, and decreases following infection. How this population decrease is controlled is not fully understood, but we propose that a protein used by the CL to kill targets also triggers suicide of the CL after it has destroyed a certain number of targets. How this is achieved is the focus of this project.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $816,673.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biological sciences | cell death | cell death - apoptosis | free radicals and antioxidants | granzyme B | immune regulation | leukaemia | lysosomes | protein trafficking | serpins

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