To determine the role and mechanism of action of tissue-type plasminogen activator in the central nervous system

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491152

Funding Status
Closed

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Funded Activity Summary

Tissue-type plasminogen activator (t-PA) is used clinically to remove blood clots. Recently, a role for t-PA in the brain was discovered where under pathological conditions it can promote ischaemic and excitotoxic brain injury. This project will examine the mechanisms by which t-PA promotes injury to brain cells. It is anticipated that results obtained could be used to devise a means to reduce t-PA toxicity in the brain that would be of therapeutic benefit for patients with ischaemic stroke.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $504,097.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

NMDA | excitotoxicity | fibrinolysis | plasminogen | stroke | stroke-cerebral ischaemia | thrombolysis treatment | thrombosis

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