Post-transcriptional regulation of plasminogen activator inhibitor 2 gene expression

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491151

Funding Status
Closed

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Funded Activity Summary

Plasminogen activator inhibitor type 2 (PAI-2) is a protease inhibitor that has intracellular and extracellular functions. The PAI-2 gene is highly regulated at the level of PAI-2 mRNA stability. We have identified regions within the PAI-2 transcript essential for this regulation and a number of novel proteins that engage these regions. This project is aimed at understanding how these and other proteins control PAI-2 expression at the mRNA level.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $508,838.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Fibrinolysis | RNA binding protein | cancer | mRNA stability | post-transcriptional regulation | protease inhibitor | proteolysis

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