Does NADPH oxidase link gender, hormone replacement therapy and outcome after stroke?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491133

Funding Status
Closed

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Funded Activity Summary

This project will assess whether the reduction of a novel mechanism to open brain arteries (i.e. via activation of 'Nox' proteins and generation of oxygen radicals) is a possible explanation of why hormone replacement therapy (HRT) increases the risk of stroke in postmenopausal women. We will compare brain artery function of normal mice with those deficient in certain Nox genes in models of menopause, HRT and stroke. This knowledge should lead to safer stroke therapies in women and men.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $481,439.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

brain | cerebral ischaemia | cerebrovascular | menopause | oestrogen | oxygen free radicals | stroke | vascular function | vasodilatation | women's health

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