Characterisation of extracellular DNases of Pseudomonas aeruginosa and their contribution to disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491130

Funding Status
Closed

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Funded Activity Summary

The bacterium Pseudomonas aeruginosa causes a number of serious diseases of humans particularly of immunocompromised patients. We have found that this bacterium secretes enzymes that have the ability to digest DNA. This proposal aims to work out how this bacterium uses these enzymes to infect human tissues and escape killing by immune cells. The results from this study will help to determine if these proteins may be used as targets for the development of new anti-infective drugs.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $418,516.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial pathogen | Bacterial virulence factors | Biofilms | Hospital acquired infection | Host-pathogen interaction | Pneumonia | Pseudomonas aeruginosa | burns | cystic fibrosis | respiratory diseases

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