The role of ezrin-radixin-moesin proteins, novel binding proteins for advanced glycation endproducts, in kidney cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491123

Funding Status
Closed

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Funded Activity Summary

High glucose levels in diabetes react with proteins to form AGEs and it is thought that this reaction may lead to kidney damage, which is one of the complications of diabetes. However, how this damage occurs is not completely understood. Cells need to maintain their shape and position for an organ to stay healthy. We have shown that AGEs affect kidney cells by interacting with and disturbing the function of proteins that maintain cell shape. We now want to study how this occurs.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $493,220.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

advanced glycation endproducts | complications of diabetes | diabetic nephropathy | ezrin-radixin-moesin | glycation | protein-protein interaction | rho

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