Negative regulators of nuclear import; potential links to cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491055

Funding Status
Closed

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Funded Activity Summary

Trafficking of proteins into the nucleus is critical to mammalian cell function, relating strongly to developmental processes and cancer. We have identified a new class of molecule - negative regulators of nuclear import - that function to prevent entry into the nucleus of key regulators of the cell cycle-apoptosis, and have a potential link thereby to cancer. We propose to determine their mechanism of action, modulation by cellular signals, and how important this is to cell function-cancer.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,829.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Apoptosis | Apoptosis-Cell Cycle | Breast Cancer | Cell cycle | Development | Nuclear Transport | Phosphorylation | Protein-protein interactions | Viral oncogenes

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