Long acting Insulin: Drug design, in vitro activity through to animal model efficacy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491031

Funding Status
Closed

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Funded Activity Summary

This research will develop novel insulins that possess improved stability and activity for diabetic patients. The improved pharmacological actions of the modified insulins offer increased treatment options for patients eg. enabling less frequent or invasive medication. Our cross-disciplinary team will (i) design and synthesise insulin derivatives, (ii) explore the activity of the modified insulins by biophysical activity profiles in vitro, (iii) evaluate the in vivo stability and clinical effects.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $445,011.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - amino acids and metabolites

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetes | glucose metabolism | insulin | insulin resistance | insulin sensitivity | therapeutic agents | therapeutics

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