Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/491017

Funding Status
Closed

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Funded Activity Summary

Hepatitis B virus (HBV) infection is a major world-wide health problem, which the current treatment strategies are not ideal. Therefore understanding how HBV inteacts with the immune system is of critical importance to developing intervention strategies to promote better health outcomes. This grant will develop our novel findings that a protein produced by HBV 'blinds' the host immune system by producing a protein that blocks the innate immune response to allow HBV to replicate unchallenged.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,320.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hepatitis B | Hepatitis B Virus Infection | Immunomodulation | Immunosuppression | Inflammation | Innate Immunity | Sepsis | Signaling pathways | Toll-like receptors

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