Allosteric modulation of GPCR-mediated intracellular signalling in human embryonic stem cell derived cardiomyocytes.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/490986

Funding Status
Closed

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Funded Activity Summary

Adenosine and muscarinic receptors are cell-surface proteins that represent promising targets for a number of conditions. However, the mechanisms linking the activation of these receptors to cellular responsiveness have not been thoroughly investigated in cells of human origin. This study will use novel cutting-edge methods to measure the effects of different classes of drugs on receptor-mediated intracellular signalling in embryonic stem cell derived human cardiac cells.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: Early Career Fellowships

Funding Amount: $324,598.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | adenosine receptor | intracellular signal transduction | molecular pharmacology | muscarinic receptor

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