Genetic approaches to understand how imbalanced cytokine signalling drives the pathogenesis of emphysema

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/490957

Funding Status
Closed

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Funded Activity Summary

Emphysema is a major component of Chronic Obstructive Pulmonary Disease (COPD), the fifth leading cause of death in Australia for which there is no effective treatment. We have discovered a specific mutation in a gene called gp130 that results in the formation of emphysema in mice. This finding allows us to understand the exact mechanisms by which this mutation causes emphysema, and therefore has the potential to uncover new strategies to design novel therapies against emphysema in humans.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $519,715.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chronic Obstructive Pulmonary Disease | Early diagnosis and treatment | Emphysema | IL-6 family cytokines | Signal transduction | emphysema | knock-in mice

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