Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/490956

Funding Status
Closed

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Funded Activity Summary

Stomach cancer is the second most common cause of cancer-related deaths worldwide, and results in the yearly death of several thousand people in Australia alone. We have discovered a specific mutation in a gene called gp130 that results in the formation of gastritis and stomach cancer in mice. We are now aiming to understand the exact molecular events by which this mutation results in chronic inflammation and the subsequent uncontrolled growth of epithelial cells that line the stomach wall.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $174,800.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Early diagnosis and treatment | IL-6 family cytokines | Inflammation | Signal transduction | Stomach Cancer | cancer | knock-in mice | pathogen recognition receptors

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