Inhibition of allergic airway inflammation by nanoparticles

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/490908

Funding Status
Closed

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Funded Activity Summary

Inhaled air pollution particulate matter causes asthma exacerbations, with 'ultrafine' nanoparticles thought to play a major role. Unexpectedly, we recently found that, by contrast, administration of inert ultrafine nanoparticles prevents allergic airway inflammation. We will identify the key particle physical and chemical properties associated with this novel type of disease inhibition, study particle effects in clinically-relevant disease models and identify mechanisms of action.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,075.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Anaesthesiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Airway inflammation | Allergen induced inflammation in the respiratory tract | Allergic asthma | Asthma and allergic disease prevention | Dendritic cell | Immunomodulation | Lung homeostasis | Nanoparticle | Prevention and treatment of asthma | T cell

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