Goblet cell stress and intestinal inflammation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/488809

Funding Status
Closed

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Funded Activity Summary

We have generated mice with symptoms mirroring the inflammatory bowel disease, ulcerative colitis (UC). These mice have mutations in the gene producing the major component of the protective mucus layer in the intestine. The mutations lead to a phenomenon known as ER stress. We have shown that ER stress also occurs in UC, opening up a new understanding of this disease. The proposed research will explore links between ER stress and inflammation and test potential new treatments for UC.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $571,311.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Genetic Predisposition to Disease | Inflammatory Bowel Disease | Ulcerative colitis | endoplasmic reticulum | mucins | mucosal inflammation | nuclear factor kappa-B (NF-KB) | protein trafficking

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