Mechanisms underlying APOBEC3G restriction of HIV-1

Funding Activity

Website
http://grants.uberresearch.com/501100000925/http://purl.org/au-research/grants/nhmrc/488225/Understanding-how-the-cellular-protein-APOBEC3G-blocks-Human-Immunodeficiency-Virus

Funding Status
Closed

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Funded Activity Summary

In the fight against worldwide HIV-AIDS, understanding natural cell defenses to the HIV virus may identify new virus targets and strategies to block HIV in humans. Here, we will use state-of-the-art, high resolution, fluorescent microscopy to understand how the recently identified cell protein, APOBEC3G, blocks the HIV life cycle in human cells. We anticipate that APOBEC3G will stop HIV from invading the nucleus of human cells to defend against HIV, a strategy we can apply to new therapies.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,075.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

APOBEC3G restriction factor | Cell Biology - Green Fluorescent Protein | HIV infection | HIV-1-AIDS | Infectious Diseases | Quantitative PCR | Viral inhibitor | Viral replication | Virus replication

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