Structural basis for inhibition of malaria invasion by targeting the apical membrane antigen of Plasmodium falciparum.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/487339

Funding Status
Closed

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Funded Activity Summary

3 million children die every year from malaria infections. A leading vaccine candidate is a protein from the malaria parasite called AMA1. Humans that have been infected with malaria make antibodies to this protein which can kill parasites, however little is known about how this occurs. We aim to identify regions of the protein that generate antibodies that prevent malaria parasites from invading human cells and help in the search for a vaccine against malaria.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $434,134.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Merozoite | Plasmodium falciparum | Polymorphism mapping | epitope mapping | infant mortality | infectious disease | malaria vaccine | phage display

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