Modulation of leishmaniasis by the proinflammatory cytokines TNF

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/485807

Funding Status
Closed

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Funded Activity Summary

We have established a mouse model that has been genetically modified and cannot produce the cytokine tumour necrosis factor. This cytokine is secreted in the beginning of the inflammatory response. If these mice are infected with a parasite they are not able to heal the infection and die quickly. We can demonstrate that these mice cannot regulate the beginning inflammatory response and do not form a cellular infiltrate at the site of infection.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $288,911.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cellular Immunology | Cutaneous infection | Host-Pathogen interaction | Immundeficieny | Infection immunology | Innate immune response | Leishmaniasis | Proinflammatory cytokine | Protozoan infection

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