Inhibition of glucose-stimulated insulin secretion by Protein Kinase C epsilon

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/481340

Funding Status
Closed

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Funded Activity Summary

Type 2 diabetes is a chronic disease which occurs when the pancreas is unable to produce enough insulin for the body to cope with rising blood glucose levels after a meal, and is strongly linked to obesity. We have discovered that fat oversupply activates an enzyme in the pancreas causing defects in insulin release due to glucose. Inhibiting this enzyme helps overcome diabetes, through poorly defined mechanisms that we aim to clarify here. Our work could lead to new therapies for diabetes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $555,693.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Type 2 diabetes | cell signalling | fatty acid and phospholipid metabolism | fatty acid metabolism | insulin secretion | mitochondria | protein kinase C

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