Regulation of body composition and glucose homeostasis by the adaptor protein Grb10.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/481335

Funding Status
Closed

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Funded Activity Summary

Resistance to the hormone insulin underlies the development of Type 2 Diabetes. Loss of muscle mass in the elderly contributes to insulin resistance. Recently we identified Grb10 as a new regulator of insulin action and muscle mass. In this proposal, we aim to study how Grb10 affects development and growth of muscle and fat, and the underlying molecular mechanisms. This may lead to new strategies for improving body composition and treating the insulin resistance associated with Type 2 Diabetes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $617,256.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Glucose metabolism | Insulin action | Insulin resistance | Metabolic syndrome | Muscle growth factors | Obesity | Protein tyrosine kinase | Sarcopenia | Signal transduction | Type 2 diabetes

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