The Role of Hypoxia Inducible Factor 1a in Beta-Cell Function and Diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/481300

Funding Status
Closed

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Funded Activity Summary

HIF1a is a gene which our preliminary data shows is needed for normal beta-cell function and insulin secretion. When beta-cells cannot release enough insulin, blood sugar levels rise, and diabetes develops. This research plan will look at the effects of deletion of HIF1a and of increasing HIF1a to see how this affects function of beta-cells and - or diabetes development. This work may show that HIF1a is a potential therapeutic target for the treatment of diabetes in humans.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $362,303.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Diabetes | Hypoxia | Type 1 diabetes | Type 2 diabetes | diabetes mellitus | hypoxaemia | insulin | transplantation biology

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