Quantitative in vitro-in vivo extrapolation: Realising the promise

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/480417

Funding Status
Closed

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Funded Activity Summary

Most drugs are 'broken down', or metabolised, in the body by enzymes which are located mainly in liver. Knowing the efficiency of drug metabolism in patients is important for the discovery of new drugs and for the rational use of established drugs. This project will develop in vitro, or test-tube, approaches that predict how well a drug is metabolised in humans and whether it will interact with coadminsitered drugs. In turn, this allows prediction of drug dosage and frequency of administration.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $529,509.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry and metabolomics not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

UDP-glucuronosyltransferase | cytochrome P450 | drug clearance and interactions | drug development | drug interactions | drug metabolism | in vitro - in vivo extrapolation | in vitro models | pharmacology

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