Targeted knockdown of human SOD1 genes by non-viral gene delivery to delay onset and progression of ALS

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/480404

Funding Status
Closed

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Funded Activity Summary

Amyotrophic lateral sclerosis (ALS) is an illness of nerves resulting in a creeping paralysis and death; there is no effective treatment. We have developed immunogenes consisting of an antibody to target specific nerves and a gene that can affect it. Our immunogene will deliver genes that inhibit a mutant protein causing disease in an ALS mouse model. Successful outcomes of this research will be to encourage development of treatments both before and after the disease has developed.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $504,097.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Amyotrophic lateral sclerosis | Antibody | Gene delivery | Gene knockout | Motor neuron disease | Neurodegenerative disease | Neurological disease

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