TRF2 protein and t-loop replication in Alternative Lengthening of Telomeres

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/477106

Funding Status
Closed

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Funded Activity Summary

Telomere loss acts as a clock telling cells when to stop proliferating. Cancer cells ignore this clock and grow indefinitely by preventing the normal loss of telomeres. Little is known about one of the methods cancers use to preserve telomeres, called ALT, which is employed by some brain tumours and other cancers. We will determine if the TRF2 protein is involved in controlling ALT. This will lay the basis for future anti-cancer treatments targeted at ALT.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $398,156.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA replication | cancer | cellular immortalisation | glioblastoma multiforme | protein characterization | soft tissue sarcoma | telomeres

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