Monomeric C-reactive protein as pathogenic factor and therapeutic target in atherothrombotic disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/472666

Funding Status
Closed

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Funded Activity Summary

CRP is a plasma marker that can identify individuals at high risk for heart attack and stroke. Our preliminary data suggests that plasma CRP is not only an innocent marker, but can also be activated and thereby become a strong inflammatory stimulus by changing from a five unit to a single unit form on the surface of activated platelets. We will investigate this CRP activation in vitro, in animal models and in patients, and aim to develop new drug therapies for diseases such as heart attack.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $674,880.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atherosclerosis | C reactive protein | Cardiovascular Disease | Cardiovascular Risk Factors | Monocytes | Myocardial Infarction | Myocardial infarction | Platelets

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