The effect of follicular helper T cells (TFH) on AID regulation and selection of high affinity germinal centre B cells.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471494

Funding Status
Closed

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Funded Activity Summary

An integral component of an immune response to foreign pathogens is the production of antibodies by B cells. However, if antibodies react to self-antigens (human molecules rather than bacteria or viruses) they may also cause autoimmune diseases such as lupus. This research project is investigating the mechanisms that control antibody generation by B cells, and how these are dysregulated in autoimmune diseases, such as lupus.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2014

Funding Scheme: Early Career Fellowships

Funding Amount: $430,964.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Activation induced cytidine deaminase (AID) | Autoantibodies | Autoimmunity | B cell | Follicular helper T cells

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