Glutathione transferase-derived compounds as therapeutic agents

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471462

Funding Status
Closed

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Funded Activity Summary

Inhibition of cardiac calcium ion channels may be an effective new way of improving heart performance in patients with heart failure. This project will investigate how a glutathione transferase enzyme inhibits calcium ion channels in the heart and if small fragments of a muscle specific glutathione transferase can be used to specifically modify cardiac ryanodine receptor function. These fragments will provide the basis for the development of a new therapeutic approach.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $418,516.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry and metabolomics not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Glutathione transferase as a therapeutic agent | Inhibition of cardiac ryanodine receptor Ca channels | Modulation of cardiac contraction | Modulation of ryanodine receptors in heart failure | Ryanodine receptors as a therapeutic target | Site of GST- Ryanodine receptor interaction | Structure of GST derived peptides | cardiac ischaemia | preventing arrhythmia

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