Genetic pathology of Roquin in human autoimmune disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471439

Funding Status
Closed

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Funded Activity Summary

Lupus is a life-threatening disease in which immune responses normally targeted at germs are directed at tissue in the body. We have discovered a mouse model of lupus and elucidated an important pathway that determines whether immunity is directed at the body or at germs. Building on recent progress in understanding the genetic variation between individuals, we will use the information obtained from the mouse model to investigate the genes that regulate this pathway in people with lupus.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,466.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Emergency medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angioimmunoblastic lymphoma with dysgammaglobulinemia | Autoantibodies | Genetic susceptibility to human lupus | ICOS gene variants in lupus | Roquin gene variants | Systemic lupus erythematosus | T follicular helper cells

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