Regulation of antiviral and antiinflammatory responses by mTNF: Key role of reverse signaling by host and viral TNFR

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471426

Funding Status
Closed

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Funded Activity Summary

New and re-emerging viral infections continue to pose a major problem. We have recently discovered a hitherto unrecognized process that the body uses to regulate its response to infection. Some viruses have evolved to target this process, underscoring its importance. We will study 2 virus models, poxvirus and influenza A, to understand how this process works during infection. We will also examine the potential to exploit this process to block pathology and influence recovery from infection.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $568,501.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

host-pathogen interaction | immunopathology | infectious disease | inflammation | influenza | tumor necrosis factor (TNF) | viral pneumonia | virus infections

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