The role of connexins in blood pressure regulation: Use of a conditional gene expression system

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471421

Funding Status
Closed

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Funded Activity Summary

Cell coupling through gap junctions is said to play an important role in regulating blood flow and blood pressure. However data obtained from mice, in which specific gap junctions are deleted, may be compromised by compensatory changes in other junctions. We have validated a new method for rapidly and reversibly altering gap junctions in adult mice with oral sugar. This technique will enable us to directly determine whether interference with cell coupling affects blood flow and blood pressure.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $583,767.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Blood flow | Blood pressure regulation | Conditional gene targeting | Connexin gene expression | Endothelial dysfunction | Endothelium | Gap junctional intercellular communication | Vascular function | Vascular reactivity

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