Voltage dependent calcium channels and vascular function: do microdomains determine function?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471420

Funding Status
Closed

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Funded Activity Summary

Blood flow depends on arterial diameter which can change with contraction of muscle in the vessel wall. Calcium influx through one type of channel in the muscle cells has been considered critical, but drugs targeting these channels have not succeeded in treating the arterial spasm which occurs after stroke and head injury. Our study will investigate the existence and role of other calcium channels in brain arteries. Knowledge gained will likely lead to development of new drug targets for stroke.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $597,682.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arterial function | calcium channels | cerebral vasospasm | control of microvascular blood flow | microenvironment | pharmacology | stroke-cerebral ischemia | subarachnoid haemorrhage | vasoconstriction

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