Cell Death Pathways and Type 1 Diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/466658

Funding Status
Closed

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Funded Activity Summary

Loss of insulin-producing beta cells leads to type 1 diabetes and rejection of allogeneic islet transplants. The aim of this program is to discover ways of protecting beta cells from damage. We will do this by investigating whether blocking crucial regulators of cell death can protect mouse and human beta cells from destruction in vitro and in vivo. In doing so, we aim to prevent diabetes in mice and potentially improve the survival of islet grafts after transplantation.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2012

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $3,029,962.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Emergency medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Apoptosis | Cytotoxic T cell | Islet transplantation | Transgenic animals | Type 1 Diabetes

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