Unified model for group A streptococcal invasive disease initiation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/459103

Funding Status
Closed

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Funded Activity Summary

Streptococcus pyogenes (group A streptococcus; GAS) is a bacterium that causes human skin and throat infections as well as highly invasive diseases including necrotising fasciitis and streptococcal toxic shock-like syndrome. We have recently discovered the trigger mechanism for GAS invasive disease. We hypothesise that the initial host response at the site of infection selects for a GAS invasive phenotype. We propose to examine the chain of events which result in tissue invasion in order to understand these disease processes and allow the development of future therapeutic interventions.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $605,221.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial genetics | bacterial pathogen | necrotising fasciitis | plasminogen | streptococcal disease | streptococcal infection | streptococcal invasive diseases | streptococcus | toxic shock syndrome

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