Wnt-Ryk signaling in the establishment of major axon tracts in the embryonic mouse brain

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/456040

Funding Status
Closed

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Funded Activity Summary

The corpus callosum is the major interhemispheric commissure in the human brain, comprising approximately 3 million myelinated fibers which connect homologous regions in the neocortex. To date more than 50 different human congenital syndromes have been described in which the corpus callosum does not form leading to epilepsy and mental retardation. We have identified a new guidance molecule (Ryk) which is crucial for corpus callosum formation. This project aims to dissect that molecular mechanisms controlling Ryk signaling during corpus callosum development. Our analysis of Ryk function will advance our understanding of the molecular mechanisms underlying the formation of this important commissure.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $513,946.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

axon guidance | brain development | cell signalling | developmental neurobiology | injury and repair to nerves in spinal cord and brain | molecular neuroscience | neuron pathfinding/fasciculation | signalling pathways

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