The dynamics of gradient sensing by growth cones: timelapse imaging and mathematical modelling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/456003

Funding Status
Closed

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Funded Activity Summary

Problems in the wiring up of the brain underlie several nervous system disorders. The goal of this project is to understand better how this wiring normally forms. This will ultimately lead to a better understanding of what can go wrong with brain wiring, and how to fix such problems. It will also lead to a better understanding of how to make axons regenerate after injury. Our approach is to use a combination of timelapse imaging of neurons in culture, and mathematical modelling, to understand how the tips of the wires growing between neurons sense their environment. By comparing our experimental measurements with our theoretical results we will arrive at a detailed and accurate model of this sensing process. This will allow us to make predictions about how these developmental events normally occur in vivo, and what can go wrong.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $493,305.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Physics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

axon guidance | growth cone | injury and repair to nerves in spinal cord and brain | mathematical modelling | nervous system development | neurodevelopmental disorders | neuron pathfinding/fasciculation

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