CDK4 activity in S/G2 phases influences mitotic fidelity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/455977

Funding Status
Closed

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Funded Activity Summary

The ultraviolet radiation component of the sunlight is a major environmental factor in the development of skin cancers, including melanomas. Over the past 10 years a genetic factors have also been identified that predispose towards developing melanoma, although the connection between ultraviolet radiation and the genetic factors has remained elusive. In this study we will investigate a cellular mechanism that potentially explains the link between sunlight exposure and one of the genetic risk factors. We will also examine whether targeting the pathway this genetic factor normally operates in can deliver increased therapeutic benefit to an existing chemotherapeutic treatment.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $531,696.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

UV radiation | cell cycle | melanoma | mitosis | skin cancer | sunlight exposure | transcriptional regulation

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